Abstract submission and early registyration April 15 2012
Travel award March 1st 2012
Call for papers
All abstract will be published in a special issue on NPY-PYY-PP in Neuropeptides
Additionally, in this special issue you are invited to submit a manuscript to Neuropeptides see information in the section Proceeding
Deadline for paper submission is July 4th 2012
The history of this peptide family began with the discovery of the first pancreatic polypeptide (PP) isolated from the avian pancreas (aPP) by Kimmel and collaborators in 1975. Soon thereafter, antibodies raised against aPP were developed and PP-like immunoreactivity (ir) detected in the central nervous system (CNS) of various species. However, as attempts to extract any PP from mammalian brain remained fruitless, it was concluded that the PP-like immunoreactivity present in the brain was due to the existence of a PP-like peptide possessing a relatively different structure. This issue was resolved in 1982 when Tatemoto and co-workers isolated from porcine brain and gut extracts two PP-like peptides which they named neuropeptide Y (NPY) and peptide YY (PYY), respectively. They all consist of 36 amino acids, have molecular weight about 4200 Da and similar hairirpin like structure, also called the PP fold structure. They all belong to the same peptide family designated as the Y, NPY or PP family.
NPY-like ir is found in both central and peripheral nervous systems and represents one of the most abundant peptide found in the central nervous system. PYY is believed to act as a hormone since it was mostly found in endocrine cells of the intestine, while PP is mainly found in the pancreatic gland. This peptide family has been implicated in a broad range of biological functions in the central and peripheral nervous systems and peripheral tissues: feeding and drinking behaviors, cardiovascular functions, modulation of several neurotransmitters release, alteration of the hypothalamic-pituitary-adrenal (HPA) axis, seizures activity, anxiety and depression-like behaviors, neurogenesis, gastrointestinal functions and immune responses. There are 7 receptor subtypes in vertebrates of which 4-5 exist in mammals. In mammals, they produce their biological effects by activating 5 receptors designated and Y1, Y2, Y4, Y5 and y6 subtypes. Their receptors have been cloned and belong to the G-protein coupled receptor superfamily. Each NPY receptor subtype exhibits a distinctive pharmacological profile. They are all expressed in mamalian tissues except the y6 receptor subtype which is only found in few species such as the mouse, dog and rabbit, is a pseudogene in primates and human and it is not expressed in the rat.
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Over the past 25 years, scientist from all over the wold (America, Asia, Europe) have organized conferences to discuss specifically on NPY, PYY and PP
The first non official NPY meeting was organized by Mutt, Tatemoto and Hokfelt in Sweden
1st meeting was organized by Janet Allen and James Koening in May 1991 at
2nd conference was organized by Helen Cox and Janet Allen in August 1993 at
3th meeting was organized by William Zipf, Helen Cooke, Richard Rogers, Ian Taylor and Claes Wahlestedt in November 1995, at Newport Beach, CA, USA.
4th gathering was organized by Stephen Bloom, Michela Rossi, Tony Goldstone, Donal O’Shea, Satya Kalra and Janet Allen in October 1997, at London, UK.
5th meeting was organized by William Colmers, Helen Cox, Donald Gehlert and Rémi Quirion in April 1999, at Grand Cayman.
6th conference was organized by Herbert Herzog, Margaret Morris, Erica Potter, Amanda Sainsbury, Lisa Selbie and Annamaria Vezzani in April 2001, at Sydney, AU.
7th meeting was organized by Annamaria Vezzani, Ana Paula Silva, Armando Cristovao, Claudia Cavadas, Catarina R.Oliveira, Joao Malva and Thierry Pedrazzini in February 2004, at Coimbra, Portugal
9th meeting was organized by Akio Inui, Takayuki Naito, Ambikaipakan Balasubramaniam, Annette Beck-Sickinger, Herbert Herzog, Michael M. Meguid, Rémi Quirion, Satya P. Kalra, Seiji Shioda, Thue W. Schwartz and William R. Crowley in March 2008, at Okinawa Japan
10th International NPY-PYY-PP meeting was organized by International committee (Annette Beck-Sickinger, William Colmers, Helen Cox, Donald Gehlert and Rémi Quirion), Advisory committee (Claudia Cavadas, Herbert Herzog, Akio Inui, Satya Kalra, Dan Larhammar and Alfredo Ribeiro-da-Silva) the local Committee (Yvan Dumont, Danielle Jacques and Brigitte Guérin) June 30 2012 to July 4th 2012 In Montréal, QC, Canada.
The 11th International NPY-PYY-PP meeting will be most likely aroung summer 2014 or 2015 organized by Annette Beck-Sickinger in Leipzig, Germany
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